Star wide receiver Emmanuel Sanders and rookie receiver Isaiah McKenzie lead the Denver Broncos casualties after the week six loss to the New York Giants.
The duo both departed with ankle injuries in the second half of the 23-10 defeat, but scans have shown they avoided breaks.
Head coach Vance Joseph indicated that the pair will miss the game at the Los Angeles Chargers on Sunday.
There was also bad news on the offensive line as Billy Turner suffered a broken hand late in the game while trying to stop Giants defensive end Jason Pierre-Paul.
Turner, who looked solid on the line, was brought in at right tackle after Menelik Watson left the game with a calf problem in the second quarter.
Joseph told the media on Monday that Watson is day-to-day leaving 2016 starter Donald Stephenson or versatile lineman Allen Barbre as the healthy options to play right tackle, but the first-year head coach was unsure if they would bring someone in to bolster the line.
The Broncos could activate undrafted rookie Elijah Wilkinson (6-6, 330lbs) from the practice squad. The 23-year-old lineman joined the Broncos in May out of Massachusetts, where he started 33 of 37 games, playing all nine games at right tackle in 2016.
Joseph also said the team is considering whether to bring in someone at wide receiver with Cody Latimer still week-to-week with a knee injury.
With rookie Carlos Henderson on injured reserve, the Broncos’ healthy receivers are Jordan Taylor, Bennie Fowler III, and star receiver Demaryius Thomas, who picked up 133 yards off 10 catches against the Giants despite battling through a lower leg injury.
The Broncos could promote receiver Hunter Sharp, who serves as the seventh receiver, from the practice squad.
The Utah State product spent 2016 with the Eagles and was signed to a futures contract by the Broncos in January before being signed to the practice squad in September.
He played the final three matches of the 2017 preseason for the Broncos, hauling in two catches in each game fora total of 92 yards and a sole touchdown from Kyle Sloter against Green Bay.
Starting quarterback Trevor Siemian is expected to retain his place for the Chargers despite leaving the game briefly at the end of the second half after landing awkwardly on his non-throwing shoulder.